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Description
Addressing underlying causes is essential: Dietary modification and supplementation for vegans/vegetarians Management of gastrointestinal disorders affecting absorption Screening for coeliac disease if indicated Review of medications that may contribute to deficiencypatients should not stop prescribed medications such as metformin or proton pump inhibitors without consulting their doctor For patients on long-term metformin, the MHRA recommends considering vitamin B12 testing in those with symptoms or risk factors for deficiency, with periodic monitoring in at-risk groups
Am J Physiol 1999;276:E32635

The mechanisms by which metabolic syndrome leads to kidney disease are not completely understood, but inflammation, insulin resistance, oxidative stress, and dysfunction of the small blood vessels of the kidney are involved (Raimundo 2011)

Astragaloside IV inhibits astrocyte senescence: implication in Parkinson's disease
At the same time, the Guidelines seek to minimise disruption to patients
