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One potential explanation for this is that a necessary fuel for the conversion of NMN or NR to NAD+ is missing
It also upregulates molecular chaperones and components of the proteostasis network, such as heat shock proteins (HSP60, HSP70) and autophagy-related proteins, facilitating the removal of toxic protein species (75)

Although thoroughly reviewed in other publications, there is mounting evidence in recent years linking ferroptosis in VECs, VSMCs and macrophages to worsened atherosclerosis 62,76,77,78
