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However, these natural lines of defense in mitochondria can be altered after excessive consumption of or exposure to alcohol (ethanol) [85, 94], drugs [66, 102, 103], viruses [104], and some nutrients, including fructose [105]

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[6] [7] At millimolar concentrations, they may also modulate the redox state of the NMDA receptor complex

SM and MP wrote sections of the manuscript

C., Henry, P
