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In PD, systemic iron accumulation contributes to striatal dopamine depletion, loss of neuromelanin, and the formation of intracellular Lewy bodies, which are primarily composed of aggregated -syn

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Observational studies indicate that in most patients, an 80% reduction in aminotransferase levels occurs within the first two months, although complete normalization may take several months [98]

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It is interesting to note that although KO mice for GH receptor/GH binding protein and for GH-releasing hormone showed an extended longevity (250, 251), this effect was not observed when using targeted deletion of the GH receptor in the liver, muscle, or adipose tissue (Table 3) (252)