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H., Danhof M

TNFRSF11B/APOE double knockout mice show increased calcium deposition by vascular smooth muscle cells 45 , MGP deficiency-causing mutations in humans leads to Keutel syndrome, a disease characterized by soft tissue calcification 46 , and SOST and FRZB are negative regulators of WNT signalling that drive calcification and are increased in the plasma of people with vascular calcification 47,48

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Pramlintide as an Adjunct to Insulin Therapy Improves Long-Term Glycemic and Weight Control in Patients with Type 2 Diabetes