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It is host to trillions of microorganisms - we're talking bacteria, fungi, viruses and even parasites (and yes, I know that last one doesn't sound so nice!)

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However, knowledge of the immunopathology of autoimmune diseases have disclosed new concepts on the impact of sleep deprivation on autoimmune disease process, showing that sleep deprivation can promote a breakdown of immunologic self-tolerance

Hogstrand, C., Kille, P., Ackland, M

These effects were found to be driven by the activation of the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2)/antioxidant response element (ARE) antioxidant pathway, through the generation of reactive oxygen species (ROS)