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Although these treatments have been shown to be effective, very little thought is put into the mechanisms by which these so-called neurotransmitter imbalances occur

However, inflammatory activation of iNOS by cytokines or lipopolysaccharides enhances cellular levels of NO and results in inflammatory diseases and septic shock (38)

Decreased activity of SDH leads to the accumulation of succinate, which is rapidly oxidized, driving ROS generation through reverse electron transfer to complex I, resulting in PANoptosis in cells (Chouchani et al., 2014

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Furthermore, vitamin E has also several protein dependent functions and gene modulation effects in inflammation