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van Leeuwen 1991

While the PPAR-beta agonist GW 501516 reduced certain inflammatory responses, it did not protect against antibody-induced demyelination, suggesting that the protective effects of PPAR-beta agonists observed in vivo are primarily due to their anti-inflammatory properties rather than direct trophic effects on oligodendrocytes

LDLR / global knockout mice were housed in the same environment as C57BL/6J mice, with free access to water and a high-cholesterol diet (HCD

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