cd38 inhibitor and 5-amino-1mq combination benefits Biological Functions Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers Inhibition of CD38 enzymatic activity

This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)

doi: 10.1038/nbt831

some quote 50150 mg/day and cycles of ~812 weeks with breaks

Chemically it is not a peptide at all, so the peptide dosing mental model only partly applies: the reconstitution math is identical, but the route options are broader (a small molecule can survive and be studied by mouth in a way most peptides cannot)

We usually test before starting treatment, then after 1-3 months