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Although the specific mechanism is not completely clear at present, from the perspective of its important regulatory role on GABAergic neurons, the abnormality of ARX may affect the normal development and function of GABAergic neurons, leading to the imbalance of brain neural circuits, thus causing ASD related symptoms ( Dysfunction of GABAergic interneurons has been observed in animal models of ASD

Melatonin stimulates the nonamyloidogenic processing of APP through the positive transcriptional regulation of ADAM10 and ADAM17

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Arginine supplementation thus reduces inflammation, intestinal injury, and oxidative stress, restoring intestinal homeostasis (Qiu et al., 2019)

Novel NRF2-activated cancer treatments utilizing synthetic lethality