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The study design did not include a control group of post-bariatric patients not using semaglutide for comparison
Receptor Supersensitivity Blockade In the landmark 1997 Sikiric study published in Biological Psychiatry (PMID: 9547930), mice pretreated with haloperidol (a dopamine antagonist) developed behavioral supersensitivity to amphetamine challenge
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However, in individuals with normal B12 status, additional supplementation does not enhance metabolic rate or promote fat oxidation
