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Description
Anderson Cancer Center by researchers led by Mikhail Kolonin and Wadih Arap
IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements
Talley D
Low-grade inflammation and metabolic dysregulation frequently accompany old age [3]
Its also associated with side effects
