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One study has demonstrated that the level of GSH in lymphocytes of patients with AMN was significantly lower compared to patients with CALD (66), but another study showed GSH levels in CALD monocyte were markedly decreased, but not in patients with AMN (67), which may be an indicator to distinguish AMN from CLAD

These events collectively result in mitochondrial dysfunction, elevated ROS, and impaired protein clearance, the triad that drives S misfolding and aggregation

doi: 10.1016/s0015-0282(00)01771-4 49 ToyaMSaitoHOhtaNSaitoTKanekoTHiroiM

If the cushioning between vertebrae wears away, it can result in painful nerve irritation