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A more recent work by Torres-Alemans group, elegantly demonstrated that this process is initiated by the release of glutamate at active regions, triggering two secondary processes: a vasodilation to increase local serum IGF-I availability and an increased activity of matrix metalloprotease 9, together with cleavage from IGFBP-3
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S.CasimiroT.CorvoM
The absence of such inflammatory signals may partly underly the poor priming environments of many tumors resulting in tolerance to tumor antigens
Clin Immunol (2008) 126(3):34552
