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Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice

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However, most of the drugs mentioned in the article (such as andrographolide, rapamycin, azathioprine, JAK inhibitors, etc.) have shown potential in mechanistic studies, but their clinical translation faces three major obstacles: imprecise targeting, safety concerns, and difficulty in preventing drug resistance. Some drugs lack cell or tissue specificity, such as insufficient local drug concentration in the intestine, and are prone to systemic side effects

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In most neurotransmitter receptor interactions, control of response to a "normal" amount of neurotransmitter production is finely tuned so that there is a good balance between the amount of ligand (neurotransmitter) and the numbers of receptors so the cell receives a good response signal