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Generally, PD shows major pathology through dopaminergic neuron degeneration in the substantia nigra, causing an approximately 80% decline of dopamine levels in the striatum ( Glutamate represents the dominant excitatory neurotransmitter across central nervous system pathways

2021), Iris lactea (Kim et al

The histone deacetylases HDA6 and HDA19 maintain basal repression, enabling rapid activation upon metal exposure

Acknowledgements The authors wish to thank Hossein Ansari, Javad Tarrahi, Dr

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