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Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

Ultimately, elucidating the mechanisms that govern transitions between protective and pathological states will be critical to refine classification systems and to guide therapeutic strategies targeting astrocyte reactivity

Marks JL, Hofstetter WL, Correa AM, Mehran RJ, Rice DCKomaki R, Wei X, Allen P, Roth JA, Swisher S, Rice DC , Walsh GL, Fossella FV, Erasmus JJ, Cox JD

Intestinal serotonergic alteration together with the increase in proinflammatory cytokines also generates chronic inflammation, resulting in decreased acid secretion, breakdown of the intestinal barrier, decreased expression of enzymes necessary to digest carbohydrates, and alteration of the intestinal adaptive immune system, leading to the appearance of food intolerances and bacterial overgrowth in the small intestine