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In consequence, AKR1B1 expression is increased in tissues with elevated oxidative stress, e.g., in alcoholic liver disease or vascular inflammation (Srivastava et al., 2005), where in some cases affords a protective role (Kang et al., 2014)

This ensures nearly complete bioavailability and higher antioxidant levels, which can lead to better therapeutic effects

The clinical program then tested it for postoperative ileus a digestive condition where the gut is slow to restart after surgery

Brain Stem Control of Swallowing: Neuronal Network and Cellular Mechanisms. Physiological Reviews 81: 929969

The crosstalk between ferroptosis and other modality of cell death also needs further investigation