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In order to test the induction of oxidative stress by FA more thoroughly, we incorporated the genetically-encoded cytosolic sensor roGFP

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This is possible due to the development of nanosystems, which use supramolecular chemistry to render the nano-sized compositions relatively stable in systemic circulation and get triggered on the contact of tumor microenvironment

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AOD-9604 was advanced through Phase I and Phase II clinical trials by Metabolic Pharmaceuticals between roughly 2003 and 2007 enrolling approximately 900 participants in total

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