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DNA can be damaged by various endogenous and exogenous insults, including ROS, causing distinct forms of damage (Glorieux et al

Assists in glutathione absorption with Vitamin C

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

The ascorbate peroxidase-glutathione reductase (APX-GR) system is far efficient in detoxification of hydrogen peroxide (H 2 O 2 ) than catalase (CAT) and peroxidase (POD) and the exogenous addition of ascorbate through the nutritional solution was reported to result in marked reduction in the activities of both enzymes (Dolatabadian and Jouneghani, 2 O 2 is widely discussed (Bray et al., 2005) investigated the relationship of glutathione and AsA concentrations in the activation of plant innate stress responses through antioxidative metabolism and it was concluded that elevated levels of glutathione, its reduced form, and ascorbate deficiency triggers salicylic acid (SA) mediated signaling that is independent of H 2 O 2

Although adhesion molecules, such as ICAM-1, expressed by endothelial cells play important roles in neutrophil extravasation, Trx1 does not alter the expression of such adhesion molecules in these cells (101, 104)