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Jul 31 1993 Vojdani et al., Nutrition Research, doi:10.1016/S0271-5317(05)80799-7 In vivo effect of ascorbic acid on enhancement of human natural killer cell activity Analysis of 20 healthy subjects in the USA showing that vitamin C increases natural killer (NK) cell activity

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The second involves a signaling function related to glutathione redox status and/or concentration

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More recently, it is becoming well-recognized that a better understanding of cellular signaling pathways alternation under toxicological insult will benefit the risk assessment and early stage prediction of drug toxicity (Jennings et al., 2013)