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However, OPT6 does not seem to be a glutathione-specific transporter: it is active against a broad spectrum of peptides, including peptides that may have signaling functions in plants (Pike et al., 2009)
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Vitamin B 12 can also be absorbed by passive diffusion, but this process is very inefficient only about 1% to 2% of the oral vitamin B 12 dose is absorbed passively (2)

FEBS J 2016;283:264052 [DOI] [PubMed] [Google Scholar] 61.Nagy G, Kardon T, Wunderlich L, Szarka A, Kiss A, Schaff Z, Banhegyi G, Mandl J.Acetaminophen induces ER dependent signaling in mouse liver
