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Testosterones conversion to dihydrotestosterone further enhances this inhibitory effect, reducing CRH and AVP mRNA expression in the PVN, decreasing POMC mRNA in the pituitary, and enhancing GR-mediated feedback 83

As the upregulated cluster 1 genes resemble a proinflammatory signature characteristic for a senescence-associated secretory phenotype (SASP) [39], we examined the GNE/BMS-regulated secretome in KRAS G12V /MYC cells by Olink Explore primer extension assays (PEA) (Supplementary Fig

There are numerous dietary sources of vitamin D such as wild-caught salmon and fatty fish, cod liver oil, grass-fed butter and raw cheese, egg yolks, mushrooms, and beef liver

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These interactions modulate GS activity, influencing cellular processes such as nitrogen assimilation, carbon metabolism, and stress responses