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In a study performed to dissect the role of mGlu2 and mGlu3 receptors in the endogenous control of inflammatory pain, mice lacking mGlu2 receptors showed amplification of pain in the second phase of the formalin test, which reflects the development of nociceptive sensitization in the spinal cord [165]

Figure 4 Phosphorylation at Serine-184 of GSTP Is Crucial for Its Nuclear Translocation and Interaction with HMGB1 Protein post-translational modifications, such as phosphorylation is closely related with protein subcellular location (50)

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Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts