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Bottom line: Vitamin C is safe for both topical and internal use, but starting with a moderate supplement dose and a dedicated lip-safe topical product is the best way to avoid irritation

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This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability

Replenishing systemic stores may restore normal oxidative capacity and improves metabolic homeostasis in deficient states