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Thermo Fisher Scientific), and the supernatant was subsequently ultracentrifuged at 42,000 rpm, at 4C, for 2 h (Sorvall wX+ Ultra series using the T-647.5 rotor

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Reduction in estrogen levels throughout aging and menopausal periods is suggested to be associated with increased oxidative stress and mitochondrial dysfunction, exacerbated proinflammatory responses, and reduced synaptic plasticity (249, 254, 255)