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Keywords: comorbidities, dimethyl fumarate, glutathione-S-transferase, psoriasis, pathway Introduction Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated erythema and scaly plaques

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Accordingly, most of the markers of systemic and cellular inflammation (leukocyte counts and activation state, cytokines, acute-phase proteins, and adipose tissue-derived adipokines) found to be altered after sleep deprivation have been epidemiologically and pathogenically associated with insulin resistance, T2DM, and vascular complications 198

The concentration of glutathione is crucialaim for products with at least 0.5% glutathione content, though some effective formulations go up to 2-3%