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However, global agriculture encounters numerous challenges due to the adverse environmental impacts stemming from herbicide contamination, both at application site and offsite

Chem Rev 117(21):1338213460 Aon MA, Cortassa S, Maack C, ORourke B (2007) Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status

This rise in interest on the usage of HMPs has also been attributed to other factors including a reaction against the often severe side effects associated with the use of orthodox medications and the failure of modern medications to adequately manage some disease conditions particularly chronic ones [30]

Undoubtedly, the unavailability of such systems has therefore fundamentally hampered the advancement of efficacious CNS therapeutics (11)

Numerous lines of evidence have already shown the lack of functioning of DDR or DNA repair genes is linked to ALS development (36)