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This may vary from twice weekly to once every 2-4 weeks (source: The basics of treatment It is not understood why certain patients require more frequent B12 treatment

A symptom of B12 deficiency can be neurological problems because the nervous system uses carbohydrates as a main fuel source

However, many people with inflammatory arthritis havent been able to take advantage of the protection because of fears that the vaccine (Zostavax), which is made from weakened but live virus, could actually cause an infection in someone taking immunosuppressive drugs, such as tumor necrosis factor (TNF) inhibitors