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A noteworthy observation was that several men required concurrent use of antiestrogen therapies such as aromatase inhibitors or tamoxifen to address gynecomastia or elevated estradiol levels

doi:10.1371/journal.pone.0255482

Common symptoms include: Persistent fatigue and weakness Pale or jaundiced skin Heart palpitations and shortness of breath Nerve problems such as numbness or tingling Cognitive disturbances such as memory loss Glossitis and mouth ulcers High homocysteine levels, leading to cardiovascular issues Given the severe symptoms associated with Vitamin B12 deficiency, timely and effective treatment becomes essential

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