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Bounous et al

Biochemical reports also demonstrated that enhanced oxidative stress, dysregulated apoptosis, and extensive inflammatory reactions mediated by overexpressed inflammatory factors [such as tumor necrosis factor (TNF-), interleukin 1 (IL-1), and interleukin 6 (IL-6)] were served as the underlying mechanisms for the occurrence of various CSD-relevant diseases (810)

doi: 10.1186/s13287-021-02208-w 43 TuHZhangDQianJBarksdaleANPipinosIIPatelKPet al

Additionally, ROS can directly regulate pro-inflammatory molecules, including IL-1, high mobility group box-1 (HMGB1) and matrix metalloproteinase 9 (136)

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