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Parabacteroides Distasonis: Intriguing Aerotolerant Gut Anaerobe with Emerging Antimicrobial Resistance and Pathogenic and Probiotic Roles in Human Health

2017;9(1) pii: E10 Robles-Vera I, Toral M, Romero M, Jimnez R, Snchez M, Prez-Vizcano F, Duarte J

TLR4 activates the NF-B signaling pathway and promotes Occludin translocation to increase intestinal barrier permeability

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In turn, lactate-induced H3K18la upregulates SRSF10 expression in macrophages, eventually forming the SRSF10/glycolysis/H3K18la positive feedback loop with tumor cells and promoting M2 macrophage polarization in the tumor microenvironment (TME)