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NCM was proved in the 2 studied cases by immunohistopathology performed after surgery

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The underlying protective mechanisms for CoQ10 against natural and chemical compound toxicity included the enhancement of antioxidant enzyme activities such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, and suppression of pro-inflammatory markers such as tumor necrosis factor-alpha, interleukin-1, and IL-6

The lactam bridge protects the Asp-His and Trp-Lys bonds from endopeptidase cleavage