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The cardioprotective effects observed in vitro were confirmed in the study by Wang and colleagues, who demonstrated that daily administration of the sodium salt NaHS (80 M/day, intraperitoneally, for up to 12 weeks) significantly prevented the impairment in left ventricular systolic and diastolic functions, mitochondrial alterations (i.e., enlargement of organelles), and cardiomyocytes apoptosis in rats with HHcy induced by L-Met (2 g/kg/day, dissolved in 2.5% starch, by gavage, for 18 weeks) [131]

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10.1002/cbic.202200801

Konstantinos Pontikis [email protected], Anna Kyriakoudi [email protected] and Antonia Koutsoukou [email protected] Intensive Care Unit, First Department of Respiratory Medicine, School of Medicine, Sotiria General Hospital, National and Kapodistrian University of Athens, Athens, Greece