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Factors such as genetics, lifestyle and environment also play a considerable role

GABA is the primary "inhibitory" neurotransmitter, meaning it helps quiet the nervous system and promotes relaxation

Furthermore, dysregulation of core clock genes such as CLOCK, BMAL1, PER1/2, CRY1/2, and NPAS2, both at the transcriptional and post-translational levels, is consistently observed in PBMC samples of shift workers and may serve as early predictors of disrupted cell cycle control, DNA repair, and apoptosis

doi: 10.1016/j.tibs.2024.04.002 186

For irregular bowel movements, personalized polyherbal solutions are administered to restore GI homeostasis