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Regular monitoring of kidney function and overall response to the medicine is advised in elderly individuals

most often, first-line therapy consists of a high-potency topical corticosteroid.[62,64,71] For persons with extensive or refractory disease, oral corticosteroids are often used.[71] Additional second- or third-line treatments include topical retinoids, systemic retinoids, and phototherapy.[71] In one report, four individuals from Japan with lichen planus had resolution of the skin lesions after successful treatment of HCV with DAA therapy.[73] Another report from Japan described a patient with oral lichen planus and HCV that improved with DAA treatment.[74] More data are needed to fully understand the impact of DAA treatment on lichen planus

Energy deficiency, hypoxia, and a highly aggressive oxidative environment at the area of inflammation trigger significant endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in multiple resident cell types tangled with variety of human pathologies, including diabetes and obesity (202, 203)

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