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For instance, co-treatment with CBD and cisplatin promoted cell death in head and neck squamous cell carcinoma (HNSCC) in cellular assays and a xenograft animal model ( 19 and cisplatin showed strong synergistic effects with CIs in a range of 0.10.3 ( 19 and cisplatin did not significantly increase the iron and ROS levels in Caov-3 cells

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50 mL of NMP and 50 mg NaOH were put in a 150 mL one-neck flask, and then refluxed at 160 C for 12 h under argon protection