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The inositol trisphosphate/calcium signaling pathway in health and disease
3.1 Pharmacokinetic and Pharmacodynamic Considerations After oral and rectal administration of mesalazine, a considerable amount of the drug is excreted unabsorbed with the faeces [17]
Natural methods can also help

The short answer is that combining the two may be possible, but it should never be done without professional guidance

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