glutathione dependent transporter Metabolism - an overview The functions of inter- and

doi: 10.1056/NEJMoa1113205 82 HerrlingerURiegerJKochDLoeserSBlaschkeBKortmannRDet al

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Up-regulation of the pathway was also able to induce cell proliferation, cell cycle progression, anchorage-independent growth and resistance to chemotherapy-induced apoptosis in medulloblastoma cell lines

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The mechanistic studies have shown suppression of inflammatory mediators like nitric oxide, TNF-, and IL-10 in LPS-stimulated macrophages, as well as impairment of macrophage migration inhibitory factor (MIF) through covalent modification by PEITC [159, 160]