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In addition, elevated levels of Hcy impair cellular metabolism by impacting respiratory chain proteins [18]

doi:10.1155/2021/9949453

Ergothioneine biosynthesis is also inducible under oxidative stress, as the molecule acts as a cytoprotective antioxidant that scavenges reactive oxygen species (ROS) and stabilises cellular redox balance

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Activation of the SIRT1/Nrf2 pathway, such as by alpha lipoic acid, can modulate iron metabolism and mitigate ferroptosis by up-regulating ferritin and ferritin heavy chain 1 (FTH1), and down-regulating the iron import protein divalent metal transporter 1 (DMT1) (Zheng et al., 2023)