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Pathogens 14 (4), 302

found that single nucleotide polymorphisms confer susceptibility to inflammatory bowel disease [187]

Furthermore, a metabolic profiling study of 200 ME/CFS patients identified diminished serum amino acids essential for oxidative metabolism, alongside elevated expression of pyruvate dehydrogenase kinases (PDKs) in PBMCs, which inhibited pyruvate dehydrogenase (PDH)

These mechanisms do not operate in isolation but rather form a self-amplifying vicious cycle: mitochondrial damage exacerbates OS and promotes pathological -syn aggregation

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