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To date, only a limited number of agents have been shown to induce ICD, yet accumulating evidence indicates that several natural products possess this capacity

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Consequently, PQQ dietary supplementation decreases plasma levels of C-reactive protein and IL-6 as well as urinary methylated amines (e.g., trimethylamine N-oxide) [376] demonstrating also antiobesity effects and protection against obesity-related complications such as inflammation, non-alcoholic fatty liver disease, chronic kidney disease, and type 2 diabetes [377]

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