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The loss of Tregs in CF affected memory, but not nave, Tregs and manifested gradually with disease progression, confirmed by a positive association between lung function, measured by forced expiratory volume (FEV1%), and number of Tregs present in peripheral blood of CF patients [29,30]

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Although excess Mn can activate microglia and promote neuroinflammation (Tjalkens et al., 2017), astrocytes may be the more dominant mediator of Mn neurotoxicity in the brain

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[cited 2024 June 13];7

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