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(66) Monocytosis or heterophilia is a common response to acute and chronic inflammatory insults in animals and birds (67) because monocytes, macrophages, and dendritic cells, part of the hematopoietic system, play roles in protection and homeostasis maintenance

doi: 10.1016/j.jbspin.2025.105892 Summary Keywords NLRP3 inflammasome, oxidative stress, programmed cell death, sodium urate crystal, soluble uric acid Citation Yang Q, Xu Y, Zhang J, Xiao N, Lu H, Chen B, Yang B, Xie Z and Li Z (2026) From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy

Oxidative stress has been demonstrated to enhance the activity of protein arginine N-methyltransferase (PRMT) and reduce the activity of dimethylarginine dimethylaminohydrolase (DDAH), an ADMA-degrading enzyme, thus resulting in a rise in ADMA concentrations [69, 151, 152]

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These combined mechanisms ultimately compromise glutamate clearance capacity 66