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NOVEL MODEL SYSTEM FOR A SEVERELY COMPROMISED OXIDATIVE STRESS RESPONSE

doi:10.2174/1389201021666200320135849 Gargouri B, Carstensen J, Bhatia HS, Huell M, Dietz GPH, Fiebich BL

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In a transgenic mouse model of Parkinson's disease, active immunization with a novel vaccine (AFFITOPE, AFFiRiS) containing short peptides homologous to aSYN conjugated to a carrier caused the formation of antibodies specifically directed against the carboxy terminus of human aSYN, cleared aSYN aggregates, and decreased neuropathology

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