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There were, as proofs of the concept (the intracranial (superior sagittal sinus), portal, and caval hypertension, and aortal hypotension were counteracted) in either case, a rapid effect, reduced gross (i.e., brain swelling was rapidly counteracted) and microscopic organs lesions, congestion, and hemorrhage

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[8] Similarly, patients with gout or hyperuricemia should avoid high niacin intake, as niacin (even in nicotinamide form) can raise uric acid levels and potentially trigger gout flares
