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Even though FR and FR can transport folate into cells, this is a relatively slow process, and inefficient compared with transmembrane transporters such as RFC1

Neurosurg Focus 24:E4 [DOI] [PubMed] [Google Scholar] 23.Lee D-H, Lee EC, Lee JY, Lee MR, Shim J-W, Oh JS (2024) Neuronal cell differentiation of iPSCs for the clinical treatment of neurological diseases

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5,6 All of these work in conjunction as a storm to provide the perfect setting for endometriosis to thrive: increased immune activation, macrophage infiltration, cellular proliferation, and remodeling of the extracellular matrix (ECM)