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10.2147/IJN.S395010 [DOI] [PMC free article] [PubMed] [Google Scholar] 84.Zare I, Yaraki MT, Speranza G, Najafabadi AH, Shourangiz-Haghighi A, Nik AB, et al

In addition, it is important to recognize that the values represent an average value for nutrients or phytonutrients, and concentration varies greatly by region, season, processing, and storage

Additional mechanistic studies demonstrated that both dihexa and Nle'-AnglV, its parent compound, were effective stimulators of hippocampal synaptogenesis thus providing a rational explanation for their pro-cognitive activities
In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model

Overall, the information garnered from kratom-associated polyintoxications and the in vitro inhibitory effects of kratom (and its alkaloids) on P450 and P-gp activity suggests a high likelihood of observing additional pharmacokinetic kratom-drug interactions that affect drug pharmacodynamics