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Mass Spectrometry-based untargeted metabolomics and -glucosidase inhibitory activity of Lingzhi ( Ganoderma lingzhi ) during the developmental stages

Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

The first reflects the drugs potential under ideal adherence