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Toxic-metabolic is a clinical term that blends two mechanisms

Further, HHcy is associated with increased methylation of CBS promoter in bone marrow-derived endothelial progenitor cells [49]

This knowledge may provide new strategies for targeting the GPX4 pathway to prevent developmental, inflammatory, or aging-related diseases

Increasing amounts of wild-type or mutated BRD4 ET were incubated with 601 DNA, and the reaction mixtures were resolved on a native polyacrylamide gel

The bioinformatics tools and technologies in drug discovery mainly include biological databases (Table 1), computer-aided drug design (CADD) and omics technologies (see the omics strategies section) (Zhang et al., 2025)